Endocrine Abstracts

Obesity and thyroid function in children – cross-sectional study.Background: Obesity in children has been increasing dramatically, with a significant increase in cardiovascular and metabolic diseases risk. The role of thyroid dysfunction has been extensively analyzed in obese adults, but to a limited extent in children.Aims: To estimate the prevalence of hyperthyrotropinemia in obese children and to analyze the influence of BM...

Introduction: Polycystic ovary syndrome (PCOS) is associated with a complex altered hormonal profile. Functional mild hyperprolactinemia can be found in up to 25–30% of PCOS women. The aim of the study was to determine the incidence of hyperprolactinemia in PCOS patients and to correlate the prolactin values with hormonal and metabolic data.Material and methods: The study included 25 women, diagnosed with PCOS, according to Rotterdam criteria (mean ...

Introduction: In the interpretation of the thyroid tests in a patient treated chronically with amiodarone (AMD), the effects on the thyroid should be considered. The aim of the study was to evaluate the thyroid parameters in amiodarone-induced thyrotoxicosis (AIT), compared to endogenous hyperthyroidism.Materials and methods: The study group included 36 patients with AIT (mean age 57.6±7.8 years, 11 women (F), 25 men (M)). The mean duration of AMD-t...

Objectives: To investigate how the immune associations (IA) may have significance for diagnosis or therapy in thyroiditis.Material and method: i) Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT)=1196, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG)=73, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis)=8, D. idiopathic myxedema (hypothyroidism, no A,B,C)=69; E. control=1...

Aim: The aim of this study was to determine the relationship between subclinical hypothyroidism and prevalence of nephropathy and cardiovascular disease in type 2 diabetic patients without taking thyroid medication.Methods: Serum thyrotropin and free thyroxine concentrations were measured in 50 type 2 diabetic subjects in DC ‘Ikeda-Euromedica’ and DC ‘Med.al’ in Tirana, from September 2009 until September 2012. In a cross-sectional st...

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 12 years ago.Materials and methods: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) New description – 10 ETP: pattern 0, lack of thyroid; 1, marked hypoechogenous pseudonodular; 2, hypoecogen homogenous; 3, micronodular hypoechogenous; 4, macro (>10 mm; ±micro) nodular; 5, inhomogeneous...

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–17 years.Materials and methods: i) Diagnostic: Hashimoto’s thyroiditis (HT): a) antithyroperoxydase antibodies (ATPO) cut-off 34 IU/ml. b) If ATPO=normal, thyroiditis was considered if high antithyroglobuline antibodies (T-ATG). c) Idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, and no TRAB. ii) Patients: HT: 1196; T-ATG: 73; IM: 69. Women/me...

Background: Whereas many papers have reported on clinical and morpho pathological features of thyroid cancer with BRAFV600E mutation, a limited number of studies have been focused on the quantification of BRAF mRNA expression in thyroid tumors.The present study aimed to assess the expression of BRAF transcript in fine needle aspiration specimens, prelevated from cases with nodular thyroid disease.Material and methods: Th...

Objectives: Aim of the study was firstly to assess the prevalence of metabolic symptoms in patients with clinically silent and benign adrenal incidentalomas (AI) and secondly to determine the prevalence of C825T GNB3 gene polymorphism in AI as well as its relation to metabolic variables.Subject and methods: Group of patients consisted of 50 patients with AI of mean age 57.9±15 years and group of controls consisted of 22 subjects without AI and metab...

Objective: To study the spectrum of chromosomal anomalies in three cases as related to the phenotypic variability of patients with anomalies of disorder of sexual development.Female 18 years old with secondary amenorrhea, stigmata of Turner’s syndrome, Tanner stage II. Ultrasound showed streak gonads. Hormonal analysis revealed elevated levels of FSH, LH and a low plasma estradiol level. The chromosomal investigation showed gonosomal mosaicism 45,X(...